Antityphoid activity and phytochemical screening of azadirachta indica leaf extracts muhammad ali1, muhammad s. Almost every part of the neem treebark, branches, leaves, roots, seeds, and the trunkhas a biological application. Therapeutics role of azadirachta indica neem and their. Biological activities and medicinal properties of neem azadirachta indica kausik biswas, ishita chattopadhyay, ranajit k. Evaluation of the antiulcer activity of the leaves of. Clinical studies on the effect of neem azadirachta indica. Kutama3 and lurwanu muazu4 1department of microbiology, federal university gusau, nigeria 2desert research monitoring and control centre, yobe state university damaturu, nigeria 3department of biology, saadatu rimi. Azadirachta indica is a fast growing evergreen popular. It has been widely used in chinese, ayurvedic, and unani medicines worldwide especially in indian subcontinent in the treatment and prevention of various diseases. Mar 01, 2016 neem azadirachta indica is a member of the meliaceae family and its role as healthpromoting effect is attributed because it is rich source of antioxidant. Therefore, azadirachta indica offers another option for a safer and an effective antiulcer drug. The leaves, seeds, roots and bark of the plant possess bitter active principles in different constituents oliverbever, 1986. The best antiulcer activity is demonstrated by one of its active components, allylpyrocatechol, mainly by modulation of arginase metabolism and the shift of cytokine balance yadav et al. Assistant professor, department of pharmacy, grd pg imt, dehradun, uttarakhand, india.
Neem is a renewable resource of various useful domestic and agricultural products, including cattle feed, medicines, soap industry, nitrification inhibition, slow nutrient release manure, fuel, energy, pest control, and others. The present study focuses on the in vitro anthelmintic activity of silver nanoparticles agnps synthesized using the aqueous extract of azadirachta indica against haemonchus contortus. The objective of the present study was to investigate whether neem bark extract had similar antisecretory and antiulcer effects in. Many compounds with different pharmacological activity have been evaluated in vitro for their spermicidal activity. The inhibiting effect of azadirachta indica against dental. Antiulcer activity an overview sciencedirect topics. Antiulcer activities of aqueous extract of leaves were studied in rats, and the most probable mechanism of action was the inhibition of gastric lesions in dosedependent manner chattopadhyay et. Azadirachta indica, commonly called neem or dogonyaro in nigeria, is a plant that has found varied use in ecological, medicinal and agricultural sectors. Neem azadirachta indica is a wellknown medicinal and insecticidal plant.
The present study includes the phytochemical detection and antimicrobial activity of the leaves of azadirachta indica, a. We had studied at the medical college, trivandrum, properties of nimbidine, the bitter amorphous, neutral powder isolated from the oil expressed from the seed kernels of azadirachta indica neem in animals as well as in humans with duodenal ulcer. Faculty of medical laboratory sciences, al neelain university, khartoum, sudan. We have shown earlier that neem azadirachta indica bark aqueous extract has potent antisecretory and antiulcer effects in animal models and has no significant adverse effect bandyopadhyay et al. Azadirachta indica, pharmacological actions, medicinal applications, limonoids. The latinized name of neem azadirachta indica is derived from the persian. It is typically grown in tropical and semitropical regions. Antimicrobial activity, azadirachta indica, pathogenic bacteria, leaf and bark extract. Azadirachta indica is now used in traditional medicine as a source of many therapeutic agents.
Neem azadirachta indica plant profiler sigmaaldrich. Azadirachta indica an overview sciencedirect topics. Neem azadirachta indica has been used for centuries in asia as an insecticide, fungicide, and anticonceptional in popular medicine. Exploring indian medicinal plants for antiulcer activity. Earlier finding confirmed that neem and its constituents play. Ulcers are induced by aspirin plus pylorus ligated gastric ulceration in rats and aqueous extract of leaves is to be administered orally for 21 days, daily dose of 1 gmkg. Fresh and shade dried leaves were used for the study. Antibacterial activity of azadirachta indica neem leaf. Biological activities and medicinal properties of neem. Because of these activities neem has found enormous applications making it a green treasure. Azadirachta indica, commonly known as neem, nimtree or indian lilac, is a tree in the mahogany family meliaceae.
The extract dosedependently inhibits gastric lesions induced by restraintcold stress, indomethacin and ethanol. Earlier finding confirmed that neem and its constituents play role. Hemidesmus indicus it has been used in various diseases and disorders, such as, antinociceptive, antidiarrhoeal, renoprotective, antiatherogenic, and skin carcinogenesis. Review on biological activities of azadirachta indica. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. Medicinal and therapeutical potential of neem azadirachta. Neem azadirachta indica is a member of the meliaceae family and its role as healthpromoting effect is attributed because it is rich source of antioxidant. Ayurveda, pharmacological activity, traditional uses, botanical description, azadirachta indica. Azad free, dirakht tree, i hind of indian origin which literally means. Ulcer is a common gastrointestinal disorder which is seen among many people. All parts of neem tree used as anthelmintic, antifungal, antidiabetic, antibacterial, antiviral, contraceptive and sedative. Nonlactose fermenting nlf bacteria belonging to enterobacteriaceae. Galhardi lc, yamamoto ka, ray s, ray b, linhares re, nozawa c 2012 the in vitro antiviral property of azadirachta indica polysaccharides for poliovirus. Introduction azadirachta indica commonly known as neem, is native of india and naturalized in most of tropical and subtropical countries are of great medicinal value and distributed widespread in.
Pharmacological and non pharmacological activity of. Antimicrobial activity of azadirachta indica neem against. Introduction azadirachta indica commonly known as neem, is native of india and naturalized in most of tropical and subtropical countries are of great medicinal value and distributed widespread in the world. Azadirachta indica, commonly known as neem, has attracted worldwide prominence in recent years, owing to its. Azadirachta indica family meliaceae is indigenous to and cultivated nearly all over india. Varying concentration of each extracts 200mgml, 150 mgml, 100mgml. Momordica charantia cucurbitaceaeiscommonlyknownasbittergourd.
In stress ulcer model, it is more effective than ranitidine but less effective than omeprazole. The present investigation revealed that ocimum sanctum exhibited significant antiulcer activity by enhancing antioxidant potential of gastric mucosa thereby reducing mucosal damage. To check the antimicrobial activity of azadirachta indica neem, ocimum sanctum tulsi, mimusops elelngi bakul, tinospora cardifolia giloy and chlorhexidine gluconate chx on common endodontic pathogens like streptococcus mutans, enterococcus faecalis and staphylococcus aureus. Introduction neem is used in traditional medicine as a source of many. Neem azadirachta indica, is native of india and naturalized in most of tropical and subtropical countries are of great medicinal value and distributed widespread in the world. D college, ambala cantt, haryana, india abstract azadirachta indica is a fast growing, evergreen tree found commonly in india, africa and america. The species is presently being cultivated worldwide because of its ability to adapt to different. Melia azadirachta is well known in india and its neighbouring countries for more than 2000 years as one of the most versatile medicinal plants having a wide spectrum of biological activity. In in vitro studies, neem oil exerted an antibacterial effect and antifungal action against numerous clinical isolates. Mullick road, kolkata 700 032, india neem azadirachta indica a. Azadirachta indica, an evergreen tree, is used by several folkloric practitioners to treat peptic ulcers in india. Neem azadirachta indica is a tropical evergreen, profusely branched tree with oblique leaves and stout trunk of timber values with insectrepellant properties. Experimentation was made to evaluate the antioxidant activity of the flowers and seed oil of neem plant azadirachta indica a. The efficacy of azadirachta indica extract against malarial iwu et al.
Azadirachta indica, hemidesmus racemosus, asparagus racemosus, and musa sapientum. Antimicrobial potential of azadirachta indica against. Antifungal activity of azadirachta indica against alternaria. It has shown significant antiinflammatory, analgesic and antipyretic activity. It is one of two species in the genus azadirachta, and is native to the indian subcontinent. The plant, azadirachta indica a juss, family meliaceae is a native of asia but has now naturalized in west africa and is widely cultivated in nigeria as an ornamental as well as medicinal plant. The findings strengthen the view that a drug that possesses both antiinflammatory and antiulcer activity would be an additional benefit as most of the antiinflammatory drugs used today are ulcerogenic.
Azadirachta indica mouth wash is reported to inhibit growth of s. The seed and leaf extracts of azadirachta indica neem were screened for antifungal activity against dermatophytes and the minimum inhibitory concentration mic of azadirachta indica neem seed extracts was found to be lower than that of neem leaf when screened against different species of trichophyton and e. Azadirachta indica neem is perhaps the most useful traditional medicinal plant. In this study, phytoconstituents, antibacterial and anticancer activity of azadirachta indica a. Neem azadirachta indica introduction neem or margosa is a botanical cousin of mahogany. Antimicrobial activity in leaf extract of neem azadirachta indica against human pathogenic bacteria. The plant is perhaps one of the most studied and widely used medicinal plants of all ages. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract. Pharmacological activity of azadirachta indica analgesic effect in a study done by kumar et al.
Earlier this plant was also known as melia azadirachta l and antelaea azadirachta l. The present findings showed the presence of phytochemicals such. Mar 28, 2020 state tree of andhra pradesh neem azadirachta indica. The plant is native to asia, but has now naturalized in west africa. The chemical constituents contain many biologically active compounds that can be extracted from neem, including alkaloids, lavonoids, triterpenoids, phenolic compounds, carotenoids, steroids and. Banerjee and uday bandyopadhyay department of physiology, indian institute of chemical biology, 4, raja s. Description and medicinal uses of azadirachta indica neem. Azadirachta indica showed various pharmacological activities and have demonstrated to possess good spermicidal activity also. Our research e xtended the findings of singh and majumdar. Medicinal uses of neem azadirachta indica in human life. The antiulcerogenic activity of the leaf oil of piper betle has been reported bhattacharya et al. It may be due to the regular usage of drugs, irregular food. Invitro phytochemical and pharmacological bioefficacy.
Antityphoid activity and phytochemical screening of. It is a fast growing tree, average height 1520 m but rarely to 3540 m. The antimicrobial activity of azadirachta indica, mimusops. Evaluation of the antiulcer activity of the leaves of azadirachta indica. Toxicity profile of ethanolic extract of azadirachta. Evaluation of total phenolic contents and antiulcerogenic activity of root bark of azadirachta indica by m. Neem tree azadirachta indica is a tree in the mahogany family meliaceae, is evergreen tree found in most tropical countries. Abstractthe antifungal activity of azadirachta indica l was investigated against alternaria solani. Mechanism of antiulcer effect of neem azadirachta indica.
Abstract the effect of methanol extract of root bark of azadirachta indica was investigated in mice to evaluate the antiulcerogenic activity. Review article biological activities and medicinal properties. Kutama3 and lurwanu muazu4 1department of microbiology, federal university gusau, nigeria 2desert research monitoring and control centre, yobe state university damaturu, nigeria. Different concentrations of leaf and fruit methanol extracts viz. Early post implantation contraceptive effects of a purified fraction of neem azadirachta indica seeds, given orally in rats.
Review article biological activities and medicinal. Antimicrobial activities of alcoholic extracts of neem leaves were used. It is one of two species in the genus azadirachta, native to india and burma, growing in tropical and semitropical regions. In stress ulcer model, it is more effective than ranitidine but less. Collection of raw materials and preparation of extracts. Although previous studies have reported the antiulcer activity of neem leaf extract, the lead compound is still unidentified.
High performance liquid chromatography hplc and thin layer chromatography tlc fingerprint profile of methanol extract of a. Leaf extract was found more significant than fruit extract. The present investigation revealed that ocimum sanctum exhibited significant antiulcer activity by enhancing antioxidant potential of gastric mucosa. D college, ambala cantt, haryana, india 2department of biotechnology, s. Neem trees also grow in islands located in the southern part of iran. Medicinal and therapeutical potential of neem azadirachta indica. The mechanism of the antiulcer effect of neem leaf aqueous extract to block gastric lesions in rat has been studied with emphasis on acid secretion, oxidative damage and apoptosis. Whereas the chloroform, ethanol and methanol extracts were with sensible inhibitory effect on all tested organisms. Juss, commonly known as neem, has been extensively used in india as an ayurvedic medicine for the treatment of various diseases, such as, leprosy, intestinal helminthiasis, and respiratory disorders in children. The present study was carried out to evaluate the antiulcer activity. Phytochemical screening of the leaf extract of leaves both fresh and shade dried indicated the presence of flavonoids, terpenoids, tannins, alkaloids, steroids and glycosides. It may be due to the regular usage of drugs, irregular food habits, stress, and. Gautam palit we have highlighted some of the important plants reported for their antiulcer and ulcer.
Traditional medicine, azadirachta indica, pharmacological action, biological activity. Biological and pharmacological activities attributed to different parts and extracts of these plants include antiplasmodial, antitrypanosomal, antioxidant, anticancer, antibacterial, antiviral, larvicidal and fungicidal activities. It is one of two species in the genusazadirachta, and is native to india and burma, growing in tropical and semitropical regions. Antibacterial activity of azadirachta indica neem leaf extract against bacterial pathogens in sudan hala a.